For example, Takedatsu et al. [131] created a complex form consisting of macrophage-migration inhibitory factor (MIF) and two single schizophyllan (SPG) chains (β-d-glucan) as a new delivery system for antisense oligonucleotides, and treatment with this antisense MIF/SPG complex effectively inhibited MIF production and reduced intestinal inflammation in a dextran sodium sulfate-induced colitis mice model. This evidence concerns the gene MIF and colitis.