Certain representative proteins (HSP90AB1, COL1A2, COL3A1, and BRT-2) with functions of progesterone-mediated oocyte maturation, adrenergic signaling in cardiomyocytes, AGE-RAGE signaling pathway in diabetic complications, and ECM-receptor interaction were detected in Subcluster 4 and Subcluster 5. This evidence concerns the gene COL3A1 and diabetes mellitus.