IL6 and Insulin resistance: Environmental or genetic factors could impair intestinal integrity in obese animals and then induce gut dysbiosis [54], leading to the release of the endotoxin lipopolysaccharide (LPS) from intestinal Gram-negative bacteria into the bloodstream and subsequently leading to metabolic inflammation and insulin resistance in obese mice [55], which has been identified by the increasing levels of IL-2 and IL-6 in the M group in the present research.