The pharmacological study revealed that EP and its complex had a potent hypoglycemic effect on high-sugar and high-fat-induced diabetic mice by inhibiting insulin resistance, improving dyslipidemia, decreasing inflammatory factors, repairing pancreas damage, as well as activating the IRS/PI3K/AKT signaling pathway and regulating GLUT2 gene expression, in which the effects of HEZ were the most significant compared with M, non-ligand Zn(II), EP, and LEZ groups. Here, AKT1 is linked to Insulin resistance.