NPR2 and polycystic ovary syndrome: While the exact mechanisms of quercetin’s effects on the hormonal pathways in PCOS patients are still being examined, it was postulated by Ma et al., 2022, that increased levels of quercetin result in downregulation of the C-type natriuretic peptide/natriuretic peptide receptor 2 (CNP/NPR2) pathway, a pathway that normally results in blocked oocyte meiosis and altered ovulation when upregulated, which restores ovulatory normalcy and alleviates the menstrual symptoms of PCOS [49].