Megestrol acetate with alternating tamoxifen, medroxyprogesterone acetate/tamoxifen (alternating), everolimus/letrozole combination, progestational agents (such as medroxyprogesterone acetate and megestrol acetate), aromatase inhibitors, tamoxifen alone, or fulvestran are some examples of hormones used to treat recurrent/metastatic disease [37]. Here, CYP19A1 is linked to metastatic neoplasm.