INS and type 1 diabetes mellitus: The more flexible character of insulin administration eliminating the need for several subcutaneous daily injections, the possibility of dose adjustments in small increments and of altered basal rates throughout the day or on different occasions, i.e., during physical activity, menstruation or illness, are some of the main reasons continuous subcutaneous insulin infusion has become the predominant type of treatment for children with T1DM in many countries.