ACLY and autoimmune polyendocrinopathy: As shown in Table 1, according to the laboratory classification criteria for APS [25], patients were divided into three different profiles: triple-positive (strong LA test, aCL and aβ2GPI antibodies exceeding the 99th percentile), double-positive (aCL and aβ2GPI titres exceeding the 99th percentile and LA negative), single-positive (isolated LA, abnormal SCT and/or dRVVT, aCL/aβ2GPI below the 99th percentile).