RUNX2 and hematologic disorder: YY1 knockdown reduced cell proliferation of HL-60-sh-YY1-doxy and OCI-AML3-siYY1 cells (Supplementary Figure S3); in addition, several studies have shown that YY1 upregulation inhibits apoptosis and favors growth and cell proliferation in both solid tumors and hematological malignancies [108].