Additionally, in the TNBC cell line MDA-MB-231, pharmacologic HDAC inhibition with trichostatin A-induced re-expression of Snail, ZEB1, and ZEB2 transcription factors in DOT1L-knockdown cells reinforced the EMT and cancer stem cell-promoting function of p300 in the presence of DOT1L [74]. This evidence concerns the gene DOT1L and cancer.