TNFRSF11B and neoplasm: Nevertheless, as shown in our results, the prophylactic treatment of WT and TgRANKL mice with OPG-Fc, a dual inhibitor of mouse and human RANKL, led to a reduction in the tumor burden both in WT and TgRANKL mice, restored mammary ductal density and prevented the formation of ductal branching and neoplastic foci in adjacent mammary glands, indicating that the MPA/DMBA-induced tumors are RANKL-dependent.