Amongst the pool of PRMT1 variants, two splice variants of PRMT1 (variants v.1 and v.2) (shown in Figure 5) were reported to be significantly upregulated in CRC and their overexpression was associated with the nodal status and histological grade of tumors in colon cancer [80,81,82,83]. This evidence concerns the gene PRMT1 and malignant colon neoplasm.