Using the small interfering RNA (siRNA) system, HCC cells exhibiting p53 gene knockdown (transfected with siTP53) demonstrated increased cell survival compared to that of cells transfected with siCtrl when treated with cabozantinib in a dose-dependent manner (siCtrl vs. siTP53, p < 0.01; Figure 3E). The gene discussed is TP53; the disease is hepatocellular carcinoma.