The literature research was conducted manually, with the authors searching the PubMed database for eligible articles published before 2023 with the following keywords: ‘nectin cancer’, ‘nectin-1 cancer’, ‘nectin-2 cancer’, ‘nectin-3 cancer’, ‘nectin-4 cancer’, ‘CD111 cancer’, ‘CD112 cancer’, ‘CD113 cancer’, ‘PVRL-4 cancer’. This evidence concerns the gene NECTIN4 and cancer.