The WSI-based Immunohistochemical Feature Prediction System (WIFPS) discriminated lung cancer types on H&E slides based on the positive or negative expression scoring of characteristic biomarkers for each class (ADC: TTF-1, CK7, and Napsin-A; SCC: CK5/6, p40, and p63; SCLC: CD56, Synaptophysin, Chromogranin A, and TTF-1). This evidence concerns the gene SYP and lung cancer.