EGFR and neoplasm: In order to clarify the potential of the small molecule inhibitors to impair tumor cells’ migration capacity, a key mechanism involved in tumorigenesis and downstream of EGFR/PI3K signaling [44], MDA-MB-231 Br4 cells were incubated with each inhibitor at its IC50′s concentration, and cell migration/wound closure was monitored 24 and 48 h after scratch (Figure 5).