CEACAM5 and prostate small cell carcinoma: Patients were considered to have met AVPC-C if they had at least one of the seven features: histological evidence of small cell prostate carcinoma, visceral metastases only, predominantly lytic bone metastases, bulky lymphadenopathy or primary tumor with Gleason score of at least 8, low PSA with high volume bone metastases, elevated lactate dehydrogenase (LDH) or carcinoembryonic antigen (CEA), or short interval response to ADT.