Using miR-16-5p as an endogenous reference gene for the normalization of extracellular vesicles miRNA expression, miR-194-5p showed the highest correlation with the severity of PCa (rho = 43.3; p-value = 0.00955) in Figure 4A. A strong correlation was also reported for PSA (Figure 4B) and CRP (Figure 4C). Here, CRP is linked to posterior cortical atrophy.