Pan-cancer analysis based on TCGA data revealed that IGFBP7 was significantly upregulated in GC, esophageal cancer, and pleomorphic glioblastoma, among other cancer tissues, while its expression was downregulated in bladder cancer, renal cell carcinoma, and cervical cancer (Figure 1D). The gene discussed is IGFBP7; the disease is renal cell carcinoma.