To identify the potential relationships between DPP7 and other proteins in CRC, we conducted a PPI network analysis and identified the top five nodes with the highest degree centrality: sulfatase-modifying factor 1 (SUMF1), biotinidase (BTD), alpha glucosidase (GAA), sialic acid acetylesterase (SIAE), and fucosyltransferase 11 (FUT11). This evidence concerns the gene BTD and colorectal carcinoma.