SOD1 and neoplasm: Figure 5 demonstrates a substantial decrease in SOD and thiol content, accompanied by an elevation in MDA levels, in tumor tissue treated with lopinavir/ritonavir or its combination with 5-FU, relative to the control group. Moreover, no significant pathological alterations were observed in the heart, liver, and kidneys of animals after treatment with lopinavir/ritonavir (Figure 6).