SETD2 and angiosarcoma: Conversely, tumors located in bone were found to have enriched mutations in TSC2, FAT1, and PTPRT genes; angiosarcomas of the colon were found to have enriched mutations in the PIK3CA gene; and angiosarcomas of the scapula were found to have enriched mutations in PTPRS, ARID1A, KMT2D, SETD2, DDR2, and PAK7 genes (Figure 7).