PIK3CA and angiosarcoma: In the group of angiosarcomas, genes with enriched mutations were KDR, PIK3CA, and PTPRB in breast angiosarcoma; TP53, ASXL3, EPB41L3, SIGLEC9, SPTA1, RYR2, and LRP2 in scalp angiosarcoma; RNF214, FLT4, NTRK2, CCDC27, EPHA5, and TRRAP in chest wall angiosarcoma; and SI, POT1, PLCG1, and PIK3CA in dorsal/lumbar angiosarcoma (Figure 6).