Thus, MYC is critical for balanced hematopoiesis and is frequently overexpressed in acute myeloid leukemia, likely by oncogenic Wnt/β-catenin signaling through the specific WRE associated with the MYC promoter (MYC 5′ WRE), leading to proliferation and terminal differentiation impairment of HSCs [16,23,24,25,26]. This evidence concerns the gene MYC and acute myeloid leukemia.