Furthermore, activation of the Wnt signaling pathway is required for the survival and development of LSCs [5] and has been implicated in aberrant methylation of Wnt antagonists [27], such as Wnt inhibitory factor 1 (WIF1) and Dickkopf-1 (DKK1) in acute myeloid leukemia [28]. The gene discussed is WIF1; the disease is acute myeloid leukemia.