Still, considering the risk of adrenal crisis, some patients are over-supplemented, and there is an ongoing effort to rapidly diagnose NAI via early-morning cortisol level measurements after TSS instead of delaying diagnostics until dynamic testing of the hypothalamic-pituitary-adrenal axis can be conducted using the insulin tolerance test (ITT), corticotropin-releasing hormone (CRH), or the Synacthen® test 4–6 weeks post-surgery [2,8,9]. This evidence concerns the gene CRH and acute adrenal insufficiency.