Huang et al. profiled 138 cases of IM, as expected, revealing a higher mutation rate than normal controls (albeit much lower compared to non-hypermutated gastric cancer: 2.6 versus 6.9 mutations/Mb), with mutations in FBXW7 (a tumour-suppressor gene) appearing to recur [114]. The gene discussed is FBXW7; the disease is gastric cancer.