It was reported that piR-54265-binding PIWIL2 promotes the formation of PIWIL2/STAT3/phosphorylated SRC complex, inducing phosphorylated SRC-mediated STAT3 phosphorylation that, in turn, causes the proliferation, metastasis, and chemotherapy resistance of CRC cells [19]. The gene discussed is PIWIL2; the disease is colorectal carcinoma.