Activation of p53 favored an increase in mitochondrial respiration chain protein complexes (NADPH, ATP, COX, UQC, SDH) and a reduced glucose metabolism, by inducing TIGAR, p53R2, GAMT (R_MCL, P_all), and AIF (P_all) and by decreasing LDHA (P_all), ALDOC (P_all), ENO2 (P_all), and O-GlcNAcylation markers (up-regulated OGT, P_all; decreased OGA, P_cHL/MCL), thereby enhancing OxPhos in the three lymphomas, especially in cHL/MCL. This evidence concerns the gene TP53 and classic Hodgkin lymphoma.