Our results suggest that p53 induced autophagy in lymphoma via increased level of PRKAB1 (R_MCL, P_cHL), DRAM (R_MCL/cHL), WIPI2 (P_all), and increased APOL1 (P_ALCL) and OPTN (P_MCL) mediating protein degradation. Here, TP53 is linked to lymphoma.