However, tumor cells that possess mutations in oncogenes (IGF-1R, Ras, AKT, and mTOR pathways) and tumor suppressor genes (p53, p16, and Rb) are not only insensitive to lack of nutrients and low levels of anabolic hormones and do not become protected during fasting condition, their uncontrolled proliferation and increased requirement for many metabolites can sensitizes them to anticancer therapy. This evidence concerns the gene AKT1 and neoplasm.