VEGFA and melanoma: M2-like macrophages, activated by IL-4, IL-10, IL-13, and/or M-CSF, released by Th2, support breast, lung, colorectal, thymomas, and melanoma tumor growth by secreting growth factors (FGF2, PDGF, and VEGF) [69,70], immunosuppressive factors (iNOS, oxygen radicals or nitrogen species) [71,72,73], pro-angiogenic molecules (VEGF, FGF2, CXCL8, and IL-8), and proteases (MMP2, MMP7, and MMP9) [74,75,76].