Highly proliferative CD4- and CD8-activated T cells, activated B cells, γδIFNγ cells, cancer cells, activated DCs, M1-like TAMs, and intratumoral myeloid cells rely heavily on glucose and glutaminolytic metabolism, preferentially using aerobic glycolysis over TCA-coupled OXPHOS for ATP production [174,175,176]. The gene discussed is CD8A; the disease is cancer.