CD8A and neoplasm: Thus, chemokines may have both an antitumor role by promoting the recruitment of NK cells, CD4+ Th1 cells, and CD8+ cytotoxic T lymphocytes (CTLs) into the tumor [21,22,23,24], and a protumor role by promoting the recruitment of immunosuppressive cells such as Tregs [25,26], tumor-associated macrophages (TAMs), and MDSCs [27,28,29].