IL10+ Bregs promote immune evasion by suppressing IFN-g release by effector CD8+ and CD4+ T cell and activated NK cells, by reducing GzmB synthesis in CD8+ T cells, by inhibiting the secretion of pro-inflammatory cytokine by CD4+ T cells, and by hampering CD20-mediated lymphoma clearance by preventing macrophage activation [85,87,89]. The gene discussed is CD4; the disease is lymphoma.