Adult SHH-activated medulloblastomas display a higher mutation burden compared to their pediatric counterparts, particularly with mutations associated with the SHH pathway, mainly Patched1 (PTCH1) and Smoothened (SMO), as well as mutations in CREB binding protein (CREBBP), BRPF1, and TERT promoter [22]. Here, CREBBP is linked to medulloblastoma.