Hendrikse et al. [10] showed that mutations in the CBFA gene complex (most notably alterations in KDM6A and enhancer hijacking of PRDM6 and GFI1/GFI1B) in UBCs, the last cells to develop from the RLsvz, are responsible for group 4 medulloblastoma development. Here, GFI1 is linked to medulloblastoma.