PLK1 and medulloblastoma: Indeed, inhibiting polo-like kinase (PLK) and Aurora kinase (AURK), which are pivotal for the G2/M transition of the cell cycle, using BI-2536 and VX-680 (tozasertib), respectively, resulted in increased apoptosis of SHH-driven medulloblastoma cells in vitro and in vivo [99].