Based on consensus clustering of the immune cell abundance and immune function gene signature scores, five distinct sarcoma immune classes (SIC) were identified: (A) immune-desert, characterized by the lowest expression of gene signatures related to immune cells and vasculature; (B) immune-low; (C) highly vascularized, showing high expression of endothelial cell-related genes; (D) heterogeneous immune-high, with high expression of genes specific to immune populations, such as T-cells, CD8+ T-cells, and natural killer (NK) cells; and (E) immune-high with the highest B cell signature. Here, CD8A is linked to sarcoma.