The association with genetic causes is not well known, with only a few cases reported in which mutations occurred in the CDH1 (Cadherin 1) gene when appendiceal signet-ring cell adenocarcinoma was associated with gastric signet-ring cell adenocarcinoma [77], and also in the KRAS [72,78] and GNAS genes [10,72]. The gene discussed is CDH1; the disease is signet ring cell gastric adenocarcinoma.