As a hallmark of cancer, proto-oncogenes such as c-myc, p53, KRAS, Rb, and liver kinase B1 (LKB1) gene, protein kinase B (AKT), Mammalian target of rapamycin(mTOR), and hypoxia-inducible factors (HIFs) are often dysregulated in tumors [156]. Here, AKT1 is linked to cancer.