The M2 macrophages identified by surface expression of matrix metalloproteases (MMPs), Macrophage colony-stimulating factor (M-CSF), CSF-1 receptor (CSF1R), Programmed death-ligand 1/ligand 2 (PD-L1/L2), interleukin 10 (IL-10), prostaglandin, Transforming growth factor beta (TGFβ) are crucial in remodeling tumor tissue, subduing host immune responses channeling oncogenic microRNA (miRNA) loaded extracellular vesicles [30,31]. The gene discussed is IL10; the disease is neoplasm.