Interestingly, this “epigenetic” path includes a region enriched in G-protein-coupled receptors (Figure 5c), which play a crucial role as signaling transducers in the development of CRC [61] in promoting EMT [62], where particular G-protein-coupled receptors (GPCRs) such as ADGRF5 [63] and ARRB1 and ARRB2 [64] were identified as EMT- and poor survival markers in CRC. This evidence concerns the gene ARRB1 and colorectal carcinoma.