SMAD4 and colorectal carcinoma: Key genes frequently mutated and/or deregulated in CRC and CRLM, including APC, FBXW7, SMAD4, PIK3CA, WNT5A, and ATRX, are found adjacent to the minHR metagene, suggesting that their upregulation is associated with better prognosis (compare Figure 7a, left map and Figure 1c).