LGR5 and colorectal carcinoma: Components of the PRC2 such as EZH2 and SUZ12 (located in spot C) can facilitate these transitions and promote CRC stem-like cells (as indicated by the stemness marker LGR5 in spot C, see below) via repressive interactions with their targets (located in the plasticity plateau) in concert with changes to histone and DNA methylation in CIMP genes.