Accumulation at the tumor sites;ROS generation;Apoptosis and necrosis;Blocking the cell surface-expressed PDL1;Sensibility to MMP-2;Accumulated at the lymphatic system;Intratumorally secretion of TNF-α, IFN-γ, IL-1β;Intratumor infiltration and proliferation of CD8+ T cells;Up regulate memory T cells (TCM; CD3+CD8+CD44+CD127+);Inhibited tumor metastasis. This evidence concerns the gene TNF and neoplasm.