HMGB1 and neoplasm: Induction of Fenton reaction;ROS generation;Apoptosis induction;CRT, ATP secretion and HMGB1 release;Release/exposure of DAMPs;Maturation of DCs;M1-like repolarization of macrophages;Immunogenic cell death;Increase the proportion of the mature DCs (CD11c+CD80+CD86+) and M1-like macrophages in the primary and distant tumor;Downregulation of Tregs, MDSCs and M2.