For BC where CD34-positive stromal cells are present inside the tumor stroma, some authors suggested that CD34-positive BC stromal cells/telocytes are precursors for αSMA-positive stromal CAFs [27], and this may explain divergent expression of two markers from the ability of CD34-positive stromal cells to dedifferentiate into αSMA-positive CAFs. The gene discussed is ACTA1; the disease is neoplasm.