Similar to CD34_CAFs which have the ability to transdifferentiate into endothelial cells which may favor new blood vessel development, podoplanin-positive CAFs [80], which recently received more attention in breast cancer, may be assessed as potential precursors for the development of new tumor lymphatics, for promoting tumor progression invasion and metastasis, or for serving as a target for personalized therapy [81]. The gene discussed is PDPN; the disease is breast cancer.