Divergent expression of CD34-positive fibroblasts in breast normal tissue and alpha smooth muscle actin (αSMA) cancer-associated fibroblasts (CAFs) inside breast cancer (BC) stromal compartment is not a new topic in the field [6,7,8,9,10], but its prognostic and therapeutic impact is still controversial [8,11] and incompletely understood [12,13,14,15]. The gene discussed is ACTA1; the disease is cancer.