Otherwise, patients with isolated +8 and without mutations in neither STAG2, SRSF2 nor RUNX1, showed a similar age, hemoglobin level, absolute neutrophils count and outcome to MDS patients without +8, classified as low risk by the IPSS-R, but a higher percentage of BM blasts and lower levels of platelets and ring sideroblasts (Figure 2b,c, Table S6). This evidence concerns the gene RUNX1 and myelodysplastic syndrome.