Our group showed that men with MDS/MPN neoplasms have a higher number of somatic mutations and a greater number of high-risk mutations (ASXL1, EZH2, RUNX1, SETBP1, NRAS, STAG2), which were associated with a higher risk of AML transformation and worse survival [8]. This evidence concerns the gene RUNX1 and acute myeloid leukemia.