Some of the most frequently mutated genes in CMML are implicated in cellular processes, including epigenetic control, such as TET2 and ASXL1; RNA splicing, including SRSF2; cell signaling, such as CBL and NRAS; and transcription and nucleosome assembly, including RUNX1 and SETBP1 [9,10,11,12,13,14,15,16,17]. The gene discussed is ASXL1; the disease is chronic myelomonocytic leukemia.