Since prostate activity is controlled by estrogens, androgens, and sex hormone-binding globulin (SHBG) responsible for the transport of sex hormones to their target cells, the correlation of omentin, sex steroids, SHBG, as well as metabolic syndrome and age was investigated in PC patients by Borowski & Siemińska [83]. The gene discussed is SHBG; the disease is pachyonychia congenita.