Patients with higher omentin-1 levels had an increased risk of colorectal cancer regardless of age; BMI; waist-to-hip ratio (WHR); HOMA-IR; cholesterol and triglyceride concentrations; lifestyle; medications taken; family history of colorectal cancer or diabetes; and levels of adiponectin, leptin, visfatin, and resistin. This evidence concerns the gene RETN and colorectal cancer.