CD274 and gastric adenocarcinoma: In a cohort analysed by Alexandrov et al., APOBEC signatures were present in <50% of all gastric cancer samples, indicating that this feature was not common for all gastric adenocarcinoma tumours and could therefore be useful for patient stratification in combination with other markers, such as PD-L1 positivity, TMB, and EBV infection status [31].