Although signature SBS36 was not identified in gastric cancer samples in a study published by Alexander et al. in 2020, signature SBS18, present in gastric cancer samples, has a similar profile (Pearson correlation coefficient of 0.77) and possibly indicates a similar underlying mechanism, MUTYH mutations and defective base excision repair, which needs further validation [31,131]. This evidence concerns the gene MUTYH and gastric cancer.