PIK3CA and cancer: WES of MUTYH-associated polyposis in colorectal cancer revealed a distinct mutational pattern, SBS36 with frequent 8-oxoG:A mismatches in cancer driver genes (APC, KRAS, PIK3CA, FAT4, TP53, FAT1, AMER1, KDM6A, SMAD4, SMAD2) [131].