CD274 and gastric adenocarcinoma: According to the TCGA study on 295 primary gastric adenocarcinoma samples, around 8.8% were characterised as EBV positive (EBV+) with distinct molecular characteristics—mutations in PIK3CA and ARDN1A, DNA hypermethylation, overexpression of PD-L1/2, amplification of ERBB2 and JAK2, low rate of TP53 mutations, and intestinal subtype [22].