CD274 and cancer: Some of the altered genes are already serving as treatment targets, e.g., PDL-1, ITBG2, TGFB1, and c-JUN, in many cancer types, including lung cancer [48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82].