In any case, mitochondrial structure and its proteomic composition is certainly altered in a large number of carcinomas [115,136,137,138,139] and, as recently reviewed [35], many of the mitochondrial proteins involved in OXPHOS and in other mitochondrial activities remain unaltered or inhibited when compared to their non-tumor adjacent tissues (NAT). This evidence concerns the gene BRD2 and carcinoma.