TXN and carcinoma: Interestingly, in the RPPA study of LUAD carcinomas, machine learning provided a highly significant signature of metastasis (p = 3.17 10−19) that included the expression of β-F1-ATPase, IF1, superoxide dismutase (SOD2), thioredoxin (TRX), peroxiredoxin 6 (PRX6) and 4-hydroxynonenal (4-HNE) modification of proteins [20].