In these studies, cancer cells overexpressing IF1 restrain OXPHOS, enhance glycolysis and trigger the production of a mtROS signal that activates transcription of the NFκB promoter which results in protecting cells from death-inducing agents [20,75,85,147,179]; in other words, it would initially appear that IF1 is favoring a phenotype prone to cancer progression. Here, NFKB1 is linked to cancer.