BRCA1 and ovarian serous adenocarcinoma: UWB1.289 cells had been derived from a patient with serous ovarian cancer with a pathogenic loss-of-function mutation in BRCA1 (2594delC) and the absence of BRCA1 wild-type transcripts [32], which we reconfirmed in a representative early cell passage (Supplementary Table S1), and a deletion of the wild type allele, resulting in BRCA1 loss-of-function HR-deficiency.