Adjuvant chemotherapy improved OS in the majority of the subgroups, regardless of age group, gender, any history of diabetes, serum albumin level, and eGFR level; however, patients with CCI ≥ 8 (HR: 1.17, 95% CI: 0.93–1.47, p = 0.168) did not benefit from adjuvant chemotherapy. The gene discussed is ALB; the disease is diabetes mellitus.