Interestingly, C-X-C chemokine receptor type 4 (CXCR4), a receptor widely reported to regulate extramedullary myeloma, was found to induce VCAM1 secretion in non-small cell lung cancer via the regulation of the metalloproteinase, ADAM17 [15,53]. The gene discussed is ADAM17; the disease is non-small cell lung carcinoma.