SREBF1 and neoplasm: Several critical signaling pathways, such as phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB, Akt)/mammalian target of rapamycin (mTOR), epidermal growth factor receptor (EGFR), and Ras, can regulate SREBP1/2 activation to mediate tumor growth and progression [46].