MEN1 and neoplasm: A combined Cre-LoxP model targeting MEN1 and β-Catenin would cause a decrease in tumor formation and aggressiveness when compared to MEN1-alone deletion, demonstrating a role for β-Catenin in tumorigenesis for these mice [144]. Another MEN1 deletion model was described using a beta-cell-specific, tamoxifen-induced RIP2 promoter [145].