Recently, we have evaluated the effect of non-surgical periodontal treatment (NSPT) on periodontal clinical parameters and systemic blood pressure in patients with combined hypertension and periodontitis stage III grade B. The results of this study demonstrated that NSPT significantly reduced the blood level of C-reactive protein, although there were no significant reductions in the blood pressure parameters after NSPT [22]. The gene discussed is CRP; the disease is periodontitis.