Table 1 displaying univariate analysis identified the following factors as associated with AKI; comorbidities (diabetes mellitus, obesity, and chronic kidney disease); CCI; severity scores (SOFA and SAPS); mean arterial pressure; leucocyte count; D-dimer; urea and CRP on admission; positive fluid balance and cumulative fluid balance at day 3; IMV; ICU LOS; shock during ICU stay; post-intubation hypotension; septic shock and right heart failure. The gene discussed is CRP; the disease is Shock.