While blood pressure plays a significant role in left ventricular (LV) remodeling in CKD, other CKD-related factors, such as chronic inflammation, elevated levels of calcium and phosphorus, uremic toxins, anemia, fluid overload, vascular calcification, and high serum fibroblast growth factor 23 levels, have also been implicated in the structural and functional changes of the heart in patients with CKD [13]. The gene discussed is FGF23; the disease is chronic kidney disease.