Based on the NANETS (North American Neuroendocrine Tumor Society) and ENETS (European Neuroendocrine Tumor Society) guidelines, patients with G1/G2 ANENs with a diameter of >20 mm, G3, and NEC should undergo right hemicolectomy, while G1/G2 tumors between 10 and 20 mm in diameter located at the base of the appendix and with positive surgical margins, metastases to lymph nodes, angioinvasion, infiltration of the mesoappendix of >3 mm, and Ki-67 > 3%, a hemicolectomy should be considered [6,31,32]. Here, MKI67 is linked to neoplasm.