Hyperinsulinemia promotes insulin-like growth factor 1 (IGF-1) synthesis in ovarian interstitial cells, thereby intensifying the effect of LH on follicular membrane cells, leading to increased androgen production and reduced levels of sex-hormone-binding globulin (SHBG), ultimately resulting in elevated free testosterone levels [4,5]. The gene discussed is SHBG; the disease is Hyperinsulinemia.